Daids pab branch chief worked in daids pab from 2009 20, then september 2016 present fun facts. Request pdf risk factors for perinatal human immunodeficiency virus transmission in patients receiving zidovudine prophylaxis. On february 21, 1994, the national institutes of healths national institute of allergy and infectious diseases niaid and national institute of child health and human development nichd announced preliminary results from a randomized, multicenter, doubleblinded clinical trial of zidovudine zdv to prevent hiv transmission from mothers to their infants aids clinical trials group actg protocol 076. Findings from the aids clinical trial group actg 076 demonstrated that with a particular regimen of azt zidovudine, the incidence of perinatal hiv.
Protocol this trial protocol has been provided by the authors to give readers additional information about their work. Actg 076 is a phase iii, randomized, doubleblind, placebocontrolled clinical trial, designed to evaluate whether zidovudine azt administered to hivinfected pregnant women and their infants could reduce the rate of transmission from mother to infant. Injectable preexposure prophylaxis for hiv prevention raphael j. The preventive measures established for the aids clinical trial group protocol 076 actg 076. Zidovudine for the prevention of hiv transmission from. Timeline 1994 the ryan white hivaids program a living history. Copies can be purchased from superintendent of documents, u. Actg 076 is a phase iii, randomized, doubleblind, placebocontrolled clinical trial, designed to evaluate whether zidovudine azt administered. Pediatric aids clinical trials group protocol 076 study group to. One of the strategies implemented for diminishing the frecuency of infection in infants is zidovudine treatment of motherchild unit according to the protocol actg 076 that demostrated an important reduction in vertical transmission. The main route of human immunodeficiency virus hiv infection in children is from mother to child. Injectable preexposure prophylaxis for hiv prevention. Pdf evaluation of preventive measures for motherto.
Since the 076 study 16 clinical trials in the mid 1990s were conducted in from accounting 076 at university of california, irvine. In particular, the pediatric aids clinical trials group actg protocol 076 study was launched in the united states and france in 1991 to test the efficacy and safety of zidovudine in preventing mothertoinfant hiv transmission. Zdv to prevent perinatal hiv transmission actg protocol 076. Zidovudine for the prevention of hiv transmission from mother to.
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